IMPORTANT ANNOUNCEMENT: Application maintenance is scheduled of Electronic Submission System (ESS) which requires momentary downtime beginning on November 19, 2026, at 7:30 PM EST. During this scheduled downtime, our system will not accept FWA or IRB registration submissions. We expect the system to be unavailable for approximately 1-2 hours. Thank you for your patience as we complete the ESS system updates. Please contact IRBorFWA@hhs.gov if you have questions or need assistance.
This system allows an institution or organization (IORG) to submit an application for new IRB registration, or update or renew an existing IRB registration. Applications must be submitted electronically unless an institution lacks the ability to do so electronically.
See our online FAQs for information about IRB registration requirements at https://www.hhs.gov/ohrp/register-irbs-and-obtain-fwas/irb-registration/irb-registration-faq/index.html .
We recommend using the instructions for registering an IRB(s) at https://www.hhs.gov/ohrp/register-irbs-and-obtain-fwas/forms/irb-registration-instructions/index.html .